{"id":2476,"date":"2025-08-28T10:36:52","date_gmt":"2025-08-28T02:36:52","guid":{"rendered":"https:\/\/www.xhrpharm.com\/weifenlei\/calcium-phosphate-series-anhydrous-calcium-phosphate.html"},"modified":"2025-09-10T15:35:47","modified_gmt":"2025-09-10T07:35:47","slug":"calcium-phosphate-series-anhydrous-calcium-phosphate","status":"publish","type":"post","link":"https:\/\/www.xhrpharm.com\/en\/industry-dynamics\/calcium-phosphate-series-anhydrous-calcium-phosphate.html","title":{"rendered":"Calcium Phosphate Series – Anhydrous Calcium Phosphate"},"content":{"rendered":"\n
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<\/p>\n\n

Introduction<\/h2>\n\n

Calcium<\/strong> hydrogen phosphate is an excellent inorganic filler with outstanding compressibility<\/strong>. Its unique particle size, morphology, and density contribute to exceptional flowability even on high-speed tablet presses.<\/p>\n\n

Calcium Hydrogen Phosphate: Also known as dicalcium phosphate, it is a white or off-white crystalline powder. Its chemical formula is CaHPO\u2084<\/sub>, and it exists in two forms: anhydrous calcium<\/strong> hydrogen phosphate (CaHPO\u2084<\/sub>) and dihydrate calcium<\/strong> hydrogen phosphate (CaHPO\u2084<\/sub>\u00b72H\u2082<\/sub>O), with molecular weights of 136.06 and 172.1, respectively. It is highly stable and offers excellent biological availability of calcium and phosphorus, making it a high-quality calcium and phosphorus supplement. The dihydrate form contains no less than 18% phosphorus and 21% calcium. It crystallizes in the monoclinic system and loses its water of crystallization when heated to 80\u00b0C, converting into the anhydrous form, which has a triclinic crystal structure. It is odorless, slightly soluble in water, soluble in dilute hydrochloric and nitric acids, and sparingly soluble in dilute acetic acid.<\/p>\n\n

Functions<\/strong><\/h2>\n\n

\ud83d\udc49Anhydrous calcium hydrogen phosphate can be used both as an excipient and as a calcium supplement. Due to the excellent compressibility and flowability of<\/p>\n\n

\ud83d\udc49Its coarse particles, it is also suitable for use in pharmaceutical preparations.<\/p>\n\n

\ud83d\udc49It facilitates easy scale-up from laboratory to industrial production. It serves as an excellent inorganic diluent, absorbent, and filler in solid dosage forms.<\/p>\n\n

\ud83d\udc49The primary deformation mechanism of coarse-grained anhydrous calcium hydrogen phosphate is brittle fracture, which reduces its strain sensitivity and further supports seamless transition from lab-scale to industrial applications.<\/p>\n\n

\ud83d\udc49When partially neutralized stearic acid is combined with 5\u201315 times its weight of an aqueous liquid, it forms a cream base.<\/p>\n\n

\ud83d\udc49With its superior adsorption capacity, it can powderize oily substances and extracts. It acts as both a filler and a binder in traditional Chinese medicine tablets, effectively adsorbing volatile oils and extracts.<\/p>\n\n

Caution with contraindications<\/strong><\/h2>\n\n

\ud83d\udc48Calcium phosphates are incompatible with tetracycline. The surface of milled anhydrous calcium hydrogen phosphate is alkaline; therefore, it should not be used in combination with drugs that are sensitive to alkaline pH.<\/p>\n\n

\ud83d\udc48Studies have shown that milled and unmilled anhydrous calcium hydrogen phosphate differ in surface acidity and alkalinity: the surface of unmilled particles is acidic. This property is highly significant for improving drug stability, particularly when using a heavy compaction process, such as transitioning from roller compaction granulation to direct powder compression, where adjusting its particle size is advisable.<\/p>\n\n

Advantages<\/h2>\n\n

1 Manufactured in a strict GMP-compliant environment, ensuring the production process is free from contamination by microorganisms, organic impurities, inorganic impurities, and residual pollutants.<\/p>\n\n

2 High purity level of 98.0%\u2013105%, with every batch undergoing microbial testing and additional specific analyses.<\/p>\n\n

3 Exhibits excellent compressibility and low friability, making it suitable for direct compression applications, including with moisture-sensitive active ingredients.<\/p>\n\n

4 Available in multiple grades to meet various API application requirements.<\/p>\n\n

5 Registered with CDE under status “A<\/strong>“.<\/p>\n\n

6 Shelf life of up to 5 years.<\/p>\n\n

Formulation product application<\/strong><\/h2>\n\n
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Introduction Calcium hydrogen phosphate is an excellent inorganic filler with outstanding compressibility. Its unique particle size, morphology, and density contribute to exceptional flowability even on high-speed tablet presses. Calcium Hydrogen Phosphate: Also known as dicalcium phosphate, it is a white or off-white crystalline powder. Its chemical formula is CaHPO\u2084, and it exists in two forms: […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[42],"tags":[],"class_list":["post-2476","post","type-post","status-publish","format-standard","hentry","category-industry-dynamics"],"_links":{"self":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts\/2476"}],"collection":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/comments?post=2476"}],"version-history":[{"count":2,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts\/2476\/revisions"}],"predecessor-version":[{"id":2478,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts\/2476\/revisions\/2478"}],"wp:attachment":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/media?parent=2476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/categories?post=2476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/tags?post=2476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}