{"id":2289,"date":"2024-07-26T13:20:00","date_gmt":"2024-07-26T05:20:00","guid":{"rendered":"https:\/\/www.xhrpharm.com\/weifenlei\/hydrophilic-lubricant-lubristartm-sodium-stearyl-fumarate.html"},"modified":"2024-11-12T18:09:20","modified_gmt":"2024-11-12T10:09:20","slug":"hydrophilic-lubricant-lubristartm-sodium-stearyl-fumarate","status":"publish","type":"post","link":"https:\/\/www.xhrpharm.com\/en\/industry-dynamics\/hydrophilic-lubricant-lubristartm-sodium-stearyl-fumarate.html","title":{"rendered":"Hydrophilic lubricant, \u2014\u2014LubristarTM Sodium Stearyl Fumarate"},"content":{"rendered":"\n<p>Sodium Stearyl Fumarate is made by esterification of maleic anhydride with octalcohol and then by isomerization into salt. Sodium fumarateSodium Stearyl Fumarate is highly compatible and is not only frequently used in pharmaceutical preparations for tablet lubricant to improve the disadvantages of tablet strength, disintegration and dissolution; 0.5-2.0%; widely used in food and chemical products.<\/p>\n\n<p>Sodium Stearyl Fumarate is white or white powder with flat spherical particles with a melting point of 224-245\u2103 (with decomposition). This product is slightly soluble in methanol, almost insoluble in water, ethanol or acetone, and has a strong stability.<\/p>\n\n<p><\/p>\n\n<figure class=\"wp-block-gallery has-nested-images columns-1 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" data-id=\"2119\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_20241031132232.jpg\" alt=\"\" class=\"wp-image-2119\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"2121\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_20241031132236.jpg\" alt=\"\" class=\"wp-image-2121\"\/><\/figure>\n<\/figure>\n\n<p><\/p>\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_202410311322361.jpg\" alt=\"\" class=\"wp-image-2123\"\/><figcaption class=\"wp-element-caption\">Electron micrographs<\/figcaption><\/figure>\n\n<p>Sodium Stearyl Fumarate is a hydrophilic lubricant, it is basically insensitive to the amount and mixing time, different use and mixing time, basically no effect on the tablet compressibility, disintegration and dissolution. Therefore, in some solid preparations, Sodium Stearyl Fumarate is a good substitute for magnesium stearate.<\/p>\n\n<h5 class=\"wp-block-heading\">\u2b50Faster disintegration and dissolution<\/h5>\n\n<p>To the LubristarTMLubricant films disintegrate faster than magnesium stearate as a lubricant.<\/p>\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_202410311322362.jpg\" alt=\"\" class=\"wp-image-2125\"\/><\/figure>\n\n<p><\/p>\n\n<h5 class=\"wp-block-heading\"><strong>\u2b50<\/strong>Outstanding hybrid performance<\/h5>\n\n<p><\/p>\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_20241031132237.jpg\" alt=\"\" class=\"wp-image-2127\"\/><\/figure>\n\n<p><\/p>\n\n<p>Compared to magnesium stearate, with LubristarTMDo lubricant film, even in a longer mixing time will not appear lubrication problems, and can get a better hardness.<br\/>LubristarTMNot sensitive to the mixing time <\/p>\n\n<h5 class=\"wp-block-heading\"><strong>\u2b50<\/strong>Improve compressibility<\/h5>\n\n<p>The slices weighed 500mg, 12mm round flat flush and mixed for 3min.LubristarTMThe prepared films have better mechanical stability.<\/p>\n\n<p><\/p>\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_202410311322371.jpg\" alt=\"\" class=\"wp-image-2129\"\/><\/figure>\n\n<p><\/p>\n\n<h5 class=\"wp-block-heading\"><strong>\u2b50<\/strong>Good API compatibility<\/h5>\n\n<p>Sodium fumarate is relatively inert and an ideal lubricant for high-speed direct compression, and also accelerates product development and improves the bioavailability of some APIs. At present, the marketed preparations of stearic sodium fumarate are ibuprofen, salicylic acid, group doprel, ramipril, nifedipine, amlodipine, amlodipine, fellodipine, omeprazole, etc.<\/p>\n\n<p><strong>\u2b50Have better taste (no metal taste)<\/strong><\/p>\n\n<p><strong>\u2b50 LubristarTMLess sensitive to the increase in the mixing time<\/strong><\/p>\n\n<p><strong>\u2b50 Improve the appearance of the effervescent fluid<\/strong><\/p>\n\n<p>In the effervescent tablets, because magnesium stearate is hydrophobic, it will make the surface of the liquid float white insoluble material, affecting the overall appearance and drinking taste. Sodium stearic fumarate improves this kind of problem very well.<\/p>\n\n<h5 class=\"wp-block-heading\">Application<\/h5>\n\n<p><\/p>\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_202410311322372.jpg\" alt=\"\" class=\"wp-image-2131\"\/><figcaption class=\"wp-element-caption\">Sitagliptin metformin sustained-release tablets<\/figcaption><\/figure>\n\n<p class=\"has-text-align-center\">Inactive ingredients: povidone, hydroxypropyl methylcellulose, colloidal silica, sodium stearic fumarate, propyl gallate, polyethylene glycol and kaolin.<\/p>\n\n<p><\/p>\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_202410311322373.jpg\" alt=\"\" class=\"wp-image-2133\"\/><figcaption class=\"wp-element-caption\">Fenofibrate acid sustained-release capsules<\/figcaption><\/figure>\n\n<p class=\"has-text-align-center\">Inactive ingredients: hydroxypropyl methyl cellulose, povidone, water, hydroxypropyl cellulose, colloidal silica, sodium stearin fumarate, methacrylic acid copolymer, talc powder, triethyl citrate.<\/p>\n\n<p><\/p>\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_20241031132238.jpg\" alt=\"\" class=\"wp-image-2135\"\/><figcaption class=\"wp-element-caption\">Oseltamivir phosphate in capsules<\/figcaption><\/figure>\n\n<p class=\"has-text-align-center\"><strong>Inactive ingredients: cross-linked with carboxylcellulose sodium, povidone K30, pre-ceminated starch, Sodium Stearyl Fumarate and talc powder.<\/strong><\/p>\n\n<p class=\"has-text-align-center\"><strong>Lubristar\u2122 Stearate Sodium Fumarate CDE is registered and you are welcome to apply for free samples.<\/strong><\/p>\n\n<p><\/p>\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/www.xhrpharm.com\/wp-content\/uploads\/2024\/10\/&#x5FAE;&#x4FE1;&#x56FE;&#x7247;_202410311322381-1024x673.jpg\" alt=\"\" class=\"wp-image-2137\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Sodium Stearyl Fumarate is made by esterification of maleic anhydride with octalcohol and then by isomerization into salt. Sodium fumarateSodium Stearyl Fumarate is highly compatible and is not only frequently used in pharmaceutical preparations for tablet lubricant to improve the disadvantages of tablet strength, disintegration and dissolution; 0.5-2.0%; widely used in food and chemical products. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[42],"tags":[],"class_list":["post-2289","post","type-post","status-publish","format-standard","hentry","category-industry-dynamics"],"_links":{"self":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts\/2289"}],"collection":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/comments?post=2289"}],"version-history":[{"count":5,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts\/2289\/revisions"}],"predecessor-version":[{"id":2295,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/posts\/2289\/revisions\/2295"}],"wp:attachment":[{"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/media?parent=2289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/categories?post=2289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xhrpharm.com\/en\/wp-json\/wp\/v2\/tags?post=2289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}